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Year : 2015  |  Volume : 32  |  Issue : 1  |  Page : 36-40

Assessment of serum insulin-like growth factor 1 and serum insulin in children with congenital heart disease

1 Department of Pediatrics, Benha University Hospital, Banha, Egypt
2 Department of Pediatrics, Benha University Hospital, Banha; Department of Clinical Pathology, Benha Teaching Hospital, Banha, Egypt
3 Department of Pediatrics, Shebeen El Kanater Hospital, Kaliobeya, Egypt

Correspondence Address:
Doaa A Elsaid
Depatement of Pediatric, Shebeen El Kanater Hospital, Kaliobeya
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-208X.170557

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Introduction Children with congenital heart disease (CHD) have been reported to show significant growth retardation both prenatally and postnatally. Different types of cardiac malformation can affect nutrition and growth to varying degrees. Objectives The aim of this study was to assess the relationship between insulin-like growth factor 1 (IGF-1) and age, height, weight, head circumference, and BMI of infants. Materials and methods This was a case-control study conducted on 45 infants and children. The study included 30 children with CHD attending the Pediatric Cardiology Unit in Benha University Hospital from December 2012 to May 2013 who constituted the diseased group (groups 1 and 2). Their ages exceeded the neonatal period. Fifteen healthy sex-matched and age-matched children served as the control group (group 3). The infants were subjected to history taking, complete clinical examination, and assessment of serum IGF-1, serum insulin, and random blood sugar. All data were recorded and analyzed in detail. Growth retardation in children with CHD was assessed. Results There was significant difference between cases of CHD and the healthy control group as regards weight and BMI. There was significant difference between infants with cyanotic and those with acyanotic CHD as regards the weight. The cyanotic group was underweight. A significant difference was found in the length between the cyanotic and the acyanotic group. Infants in the cyanotic group were of short stature. There was significant difference between the cyanotic group and the acyanotic group as regards IGF-1 concentration, with the cyanotic group having lower concentration compared with the acyanotic group. Conclusion In light of this study we found that infants with CHD had lower IGF-1 levels compared with controls. Cyanotic CHD in children caused more pronounced growth retardation in comparison with acyanotic CHD.

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