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Year : 2016  |  Volume : 33  |  Issue : 2  |  Page : 116-124

Noninvasive diagnosis of hepatic steatosis with controlled attenuation parameter (FibroScan) in chronic hepatitis C patients

1 Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Tarek F Sheta
El Mansoura
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-208X.201291

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Background/aims The gold standard for the diagnosis of hepatic steatosis is liver biopsy, which is an invasive method with some limitations. There was an increased need for a noninvasive, cost-effective method for the diagnosis of hepatic steatosis. The aim of this work was to study the controlled attenuation parameters (CAP), a noninvasive tool, for the diagnosis of hepatic steatosis in chronic hepatitis C patients. Patients and methods The study was conducted on 100 Egyptian patients with chronic hepatitis C infection (anti-hepatitis C virus seropositive with detectable hepatitis C virus-RNA) during pretreatment assessment for antiviral therapy; those patients were randomly selected from the Outpatient Clinic in The Specialized Medical Hospital, Mansoura University. All included patients were subjected to full history taking and thorough clinical examination, full laboratory investigations, including complete blood count, liver profile tests, kidney function tests, abdominal ultrasonography, liver biopsy, and transient elastography (FibroScan), including CAP. Results There was a proportional relationship between the degree of steatosis and CAP reading. There was a highly significant difference (the best cutoff value=218 dB/m) for mild steatosis, with a sensitivity of 94.4%, specificity of 82.8%, positive predictive value of 75.6%, and negative predictive value of 96.4%. Furthermore, CAP is valuable in differentiating between moderate degree of steatosis versus no and mild steatosis (cutoff value=241.4 dB/m), with a sensitivity of 100%, specificity of 83.9%, negative predictive value of 100%, and positive predictive value of 31.8 for moderate steatosis. Conclusion CAP can be used in the diagnosis of hepatic steatosis with good diagnostic performance. CAP has the advantages of being a simple, noninvasive, inexpensive, painless, operator and machine independent method, and displays good application prospects.

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