• Users Online: 225
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 33  |  Issue : 2  |  Page : 116-124

Noninvasive diagnosis of hepatic steatosis with controlled attenuation parameter (FibroScan) in chronic hepatitis C patients


1 Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Tarek F Sheta
El Mansoura
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-208X.201291

Rights and Permissions

Background/aims The gold standard for the diagnosis of hepatic steatosis is liver biopsy, which is an invasive method with some limitations. There was an increased need for a noninvasive, cost-effective method for the diagnosis of hepatic steatosis. The aim of this work was to study the controlled attenuation parameters (CAP), a noninvasive tool, for the diagnosis of hepatic steatosis in chronic hepatitis C patients. Patients and methods The study was conducted on 100 Egyptian patients with chronic hepatitis C infection (anti-hepatitis C virus seropositive with detectable hepatitis C virus-RNA) during pretreatment assessment for antiviral therapy; those patients were randomly selected from the Outpatient Clinic in The Specialized Medical Hospital, Mansoura University. All included patients were subjected to full history taking and thorough clinical examination, full laboratory investigations, including complete blood count, liver profile tests, kidney function tests, abdominal ultrasonography, liver biopsy, and transient elastography (FibroScan), including CAP. Results There was a proportional relationship between the degree of steatosis and CAP reading. There was a highly significant difference (the best cutoff value=218 dB/m) for mild steatosis, with a sensitivity of 94.4%, specificity of 82.8%, positive predictive value of 75.6%, and negative predictive value of 96.4%. Furthermore, CAP is valuable in differentiating between moderate degree of steatosis versus no and mild steatosis (cutoff value=241.4 dB/m), with a sensitivity of 100%, specificity of 83.9%, negative predictive value of 100%, and positive predictive value of 31.8 for moderate steatosis. Conclusion CAP can be used in the diagnosis of hepatic steatosis with good diagnostic performance. CAP has the advantages of being a simple, noninvasive, inexpensive, painless, operator and machine independent method, and displays good application prospects.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2443    
    Printed247    
    Emailed0    
    PDF Downloaded161    
    Comments [Add]    

Recommend this journal