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Year : 2016  |  Volume : 33  |  Issue : 2  |  Page : 95-102

Interleukin-1β in perinatal asphyxia

Neonatal Intensive Care Unit, Department of Pediatrics, Benha Teaching Hospital, Benha, Egypt

Correspondence Address:
El-Sayed A Wagdy
MD Pediatrics, Mansoura University, Benha Teaching Hospital, Benha 5432
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-208X.201289

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Background Perinatal asphyxia is a common cause of neonatal morbidity and mortality. Inflammatory cascades are involved in the pathogenesis of ischemic brain injury during asphyxia, which is mediated by cytokines such as interleukin-1β (IL-1β). Objective We determined IL-1β in cases with perinatal hypoxia to evaluate its role in the pathogenesis of this condition and its relation to the development of complications, which may be reflected on its management. Design This is a case–control study. Patients and methods The patient group included 31 full-term newborn infants diagnosed as having perinatal asphyxia who were selected from the Neonatal Intensive Care Unit in Benha Teaching Hospital. The control group included 16 full-term newborns with no natal or postnatal complications who were selected from the well baby care unit. IL-1β and C-reactive protein (CRP) were measured by the ELISA technique (highly sensitive CRP). Erythrocyte sedimentation rate (ESR) was performed by the Wintrobe method. Statistical analysis Results were analyzed and compared with 16 controls using SPSS 20. Results IL-1β was significantly higher in asphyxia cases compared with controls. In addition, it was significantly higher in cases with seizure, systemic organ failure, and in cases who developed cerebral palsy (CP) compared with those without seizure, organ failure, and CP. IL-1β correlated positively with encephalopathy stages. It showed no relation to gestational age, sex, weight, hematological data, or CRP. Conclusion We conclude that the level of IL-1β is high in cases with perinatal asphyxia. Cases with seizure, organ failure, and neurological sequelae had higher levels. It correlates positively with encephalopathy stages without relation to hematological parameters or CRP.

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