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Year : 2017  |  Volume : 34  |  Issue : 1  |  Page : 28-32

Antipsychotics-induced diabetes mellitus in rats: it is time to change

Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine; Lecturer of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Shimaa M Motawei
Faculty of Medicine, El-Gomhoria street, Mansoura city, P.O. 35516
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-208X.206897

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Introduction The use of antipsychotics has progressively increased in the last 50 years. Despite the fact that second-generation antipsychotics have shown marked therapeutic benefits in treatment of psychosis than earlier typical ones, they produce many metabolic side-effects. Aim This study aimed to measure the metabolic effects of three classes of atypical antipsychotics on albino rats. Materials and methods A total of 40 albino rats including 16 males and 24 females were grouped into four groups: group I (control group) received the control diet and tap water ad libitum; group II received olanzapine 10 mg/kg intraperitoneally, group III received respiridone 0.2 mg/kg intraperitoneally; and group IV received aripiprazole 20 mg/day intraperitoneally. Blood glucose and insulin as well as serum cholesterol, triglycerides, malondialdehyde, high-density lipoprotein, and low-density lipoprotein were measured before treatment and 60 days after continuation of treatment. Results Significant elevation in blood glucose levels, disturbance in insulin levels, and elevation in malondialdehyde, low-density lipoprotein, and total serum cholesterol levels in atypical antipsychotics-treated animals, as compared with vehicle-treated rats, were found. These effects were more prominent with olanzapine, which is a very commonly used antipsychotic, followed by respiridone. Aripiprazole produced the least disturbance in these parameters. Conclusion Individual second-generation antipsychotics disturb blood glucose and insulin levels and produce different degrees of other metabolic derangements. There is a need to introduce safer agents for clinical use.

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