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Year : 2018  |  Volume : 35  |  Issue : 2  |  Page : 145-149

Lipids and uric acid in mid-second trimester and prediction of adverse pregnancy outcome

Gynecology and Obstetric Department, Faculty of Medicine, Benha University, Egypt

Correspondence Address:
Dr. Naglaa Y.I. El-Maghraby
Gynecology and Obstetric Department, Faculty of Medicine, Benha University, El-Sharkia, 44511
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bmfj.bmfj_18_18

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Background Studies have shown that abnormal metabolism may be a potential contributor to endothelial cell dysfunction and adversely affect the pregnancy outcome. Aim To measure the concentrations of serum lipids and uric acid (UA) in the healthy nulliparous women in mid-second trimester and to assess the predictive values of these metabolic markers for adverse pregnancy outcome. Patients and methods The study was conducted on 500 healthy nulliparous women in second trimester who attended the outpatient clinic of Banha University to predict any pregnancy outcomes. Lipids and UA concentrations were measured in mid-second trimester of pregnancy, and the odd ratios and 95% confidence interval were estimated with unconditional logistics regression adjusting for maternal age and BMI. Results The mean serum UA was statistically significantly higher in preeclampsia and gestation diabetes mellitus (GDM). We found differences in patients with preeclampsia and normotensive patients (4.77±0.99 vs. 3.15±1.07 mg/dl) and patients with GDM and non-GDM (5.94±0.77 vs. 3.29±1.09 mg/dl) but not in preterm birth. A positive correlation of serum UA with adverse pregnancy outcome was found (r=0.57, P=0.00). Serum lipids were statistically significant in prediction of adverse pregnancy outcomes. The odd ratios and 95% confidence interval of triglycerides, low-density lipoproteins, high-density lipoproteins, and total cholesterol were r=0.35, P=0.00; r=0.29, P=0.00; r=0.39, P=0.00; and r=0.63, P=0.00, respectively. Total cholesterol and triglyceride were positively correlated. Conclusion The combination of serum lipid profile and serum UA in mid-second trimester can be used to predict adverse pregnancy outcomes.

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