Benha Medical Journal

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 34  |  Issue : 2  |  Page : 59--65

Serum interleukin-6 concentration and association with response to hepatitis C virus therapy for chronic hepatitis C patients


Fatma M Abd El Salam1, Naglaa E El Toukhy1, Amal A Mohamed2, Hend A Nekola3 
1 Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Benha University, Benha, Egypt
2 Department of Biochemistry and Molecular Biology, National Hepatology and Tropical Medicine Research Institute, Faculty of Medicine, Benha University, Benha, Egypt
3 Department of Hepatology, Gastroenterology and Infectious Diseases, Shebein El-Kom Teaching Hospital, Shebein El-Kom, Egypt

Correspondence Address:
Hend A Nekola
Department of Hepatology, Gastroenterology and Infectious Diseases, Shebein El-Kom Teaching Hospital, Shebein El-Kom, 13133
Egypt

Background Egypt has the highest prevalence of hepatitis C virus (HCV) in the world. Interleukin 6 (IL-6) is a pleiotropic cytokine that is elevated in chronic hepatitis C patients. IL-6 was suggested by several studies to play a major role in response to HCV therapy. Aim The aim of this work was to assess the possible role of IL-6 in the response status of patients with HCV during treatment. Moreover, we attempted to use IL-6 as a predictive factor for response in patients with chronic HCV. Patients and methods Serum concentrations of IL-6 were measured before and after treatment using a commercially available Quantikine enzyme-linked immunosorbent assay in 57 patients with chronic hepatitis C treated with sofosbuvir and simeprevir for 3 months. Results The mean values of IL-6 level in responders and nonresponders were 272.96 and 230.5 pg/ml, respectively. IL-6 levels decreased significantly after treatment in the sustained virological response group. The best cutoff point for IL-6 was 233 pg/ml with a sensitivity of 70%, a specificity of 75%, a positive predictive value of 97.2%, and a negative predictive value of 16.7%. Conclusion Virological response during HCV therapy was associated with a decrease in IL-6 level.


How to cite this article:
Abd El Salam FM, El Toukhy NE, Mohamed AA, Nekola HA. Serum interleukin-6 concentration and association with response to hepatitis C virus therapy for chronic hepatitis C patients.Benha Med J 2017;34:59-65


How to cite this URL:
Abd El Salam FM, El Toukhy NE, Mohamed AA, Nekola HA. Serum interleukin-6 concentration and association with response to hepatitis C virus therapy for chronic hepatitis C patients. Benha Med J [serial online] 2017 [cited 2017 Dec 17 ];34:59-65
Available from: http://www.bmfj.eg.net/article.asp?issn=1110-208X;year=2017;volume=34;issue=2;spage=59;epage=65;aulast=Abd;type=0